p300/CBP-associated factor (PCAF)

P300/CBP-associated factor (PCAF) is an enzyme that plays a vital role in regulating gene activity within cells. It functions as a type of protein called a histone acetyltransferase, which modifies other proteins called histones—these help organize DNA inside the nucleus. By adding acetyl groups to histones, PCAF loosens the DNA structure, making genes more accessible for activation. This process influences how genes are turned on or off, impacting functions like cell growth, development, and response to signals. PCAF's activity is crucial for maintaining normal cellular functions and can be involved in processes like cancer development when dysregulated.