nuclear receptor corepressors

Nuclear receptor corepressors are proteins that regulate gene activity by binding to nuclear receptors—proteins that control gene expression in response to hormones like estrogen or testosterone. When these receptors are not activated by their hormones, corepressors attach to them, preventing the genes from being turned on. This process helps maintain proper balance of gene activity, ensuring cells function correctly. Essentially, corepressors act as molecular switches that keep genes turned off until the right hormonal signals activate the nuclear receptors, allowing gene expression to proceed.