Neurofibillary tangles

Neurofibrillary tangles are twisted threads of protein that form inside nerve cells in the brain. They consist mainly of a protein called tau, which normally helps stabilize the cell's internal support structure. In conditions like Alzheimer's disease, tau proteins become damaged and clump together, creating these tangled structures. Their accumulation disrupts normal cell function and can lead to cell death, contributing to memory loss and cognitive decline. Neurofibrillary tangles are a hallmark of certain neurodegenerative diseases and are used by scientists to understand disease progression.