N1-Methylpseudouridine

N1-Methylpseudouridine is a modified version of a naturally occurring molecule called pseudouridine found in RNA. This modification involves adding a methyl group to pseudouridine, which helps improve the molecule’s stability and reduce immune system detection. In the context of mRNA vaccines, like those for COVID-19, N1-Methylpseudouridine enhances how efficiently the vaccine’s mRNA is translated into proteins and minimizes unwanted immune responses, making the vaccine more effective and better tolerated. It’s a key innovation that improves mRNA technology for medical applications.