N-terminally truncated Tau

N-terminally truncated Tau refers to a form of the Tau protein that has lost a part from its beginning end. Tau proteins help stabilize structures inside nerve cells called microtubules, essential for cell shape and transport. When Tau is truncated at its N-terminal (front) end, it can become abnormal and less effective at supporting these structures. This modification is often associated with neurodegenerative diseases like Alzheimer's, where it can lead to the formation of harmful protein aggregates that disrupt cell function and contribute to memory loss and cognitive decline.