Mitochondrial permeability transition pore (mPTP)

The mitochondrial permeability transition pore (mPTP) is a channel that can open in the membrane of mitochondria, the cell’s energy-producing structures. Under normal conditions, the mPTP stays closed, allowing mitochondria to generate energy efficiently. However, during stress or injury, it can open unexpectedly, causing the mitochondrial inner membrane to become permeable. This results in loss of crucial molecules, disruption of energy production, and can lead to cell death. The mPTP plays a vital role in cell health and death processes, especially in conditions like heart attack or stroke, where mitochondrial function is compromised.