MEN2 (Sipple syndrome)

MEN2, also known as Sipple syndrome, is a genetic condition that increases the risk of developing certain tumors. It primarily affects the endocrine system, leading to the overproduction of hormones. People with MEN2 often experience medullary thyroid cancer, pheochromocytoma (a tumor of the adrenal gland), and parathyroid tumors that can cause high calcium levels. This syndrome is inherited in an autosomal dominant pattern, meaning only one copy of the mutated gene from a parent is needed for a child to be at risk. Early detection and management are crucial for improving health outcomes in affected individuals.