KDM6 family

The KDM6 family consists of enzymes that modify how our genes are expressed by removing chemical tags called methyl groups from specific locations on histones, which are proteins around which DNA is wrapped. Specifically, KDM6 enzymes target and demethylate the histone H3 at lysine 27 (H3K27), a modification that typically suppresses gene activity. By removing these tags, KDM6 enzymes help activate genes necessary for various processes like development, cell differentiation, and response to signals. They play a crucial role in regulating gene expression and maintaining normal cellular functions, with implications for health and disease when their activity is disrupted.