KDM4 family

The KDM4 family are enzymes called histone demethylases that regulate gene activity by removing methyl groups from specific parts of histone proteins, which help package DNA. By modifying these histones, KDM4 enzymes influence whether genes are turned on or off, impacting processes like cell growth, development, and DNA repair. They are involved in normal cell function but can also contribute to cancer if their activity becomes abnormal. Understanding KDM4 enzymes helps in research aimed at developing targeted therapies for various diseases, including cancer.