incompatible donor-recipient pairs

Incompatible donor-recipient pairs occur when a transplant donor’s immune system identifies the donor’s organs or tissues as foreign and may attack them, risking rejection. Key factors include differences in blood types or certain immune system markers called HLA antigens. For example, if the donor’s blood type doesn’t match the recipient’s, the body may reject the organ. To prevent this, compatibility tests are conducted to find matches that minimize rejection risk, ensuring the transplant is safe and successful.