IDH1 mutations

IDH1 mutations involve changes in a gene called IDH1, which encodes an enzyme involved in cell metabolism. These mutations can alter the enzyme's normal function, leading to the production of an abnormal molecule called 2-hydroxyglutarate. This abnormal molecule can interfere with cell development and differentiation, contributing to the growth of certain cancers, especially brain tumors like gliomas. Detecting IDH1 mutations helps doctors understand the tumor's behavior and can influence treatment options and prognosis, as tumors with these mutations often respond differently than those without.