Heparin-induced thrombocytopenia (HIT)

Heparin-induced thrombocytopenia (HIT) is a rare immune response that occurs when the body develops antibodies against a combination of the blood thinner heparin and a protein called platelet factor 4. This immune reaction triggers the destruction of platelets, which are cells that help blood clot. Paradoxically, while platelet levels drop, there is an increased risk of abnormal blood clot formation, which can lead to serious complications like deep vein thrombosis or stroke. HIT typically develops within a week of heparin exposure and requires prompt diagnosis and management to prevent serious outcomes.