Hemophagocytic Lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis (HLH) is a rare, severe condition where the immune system becomes overactive, producing a storm of inflammatory cells. This excessive response leads to widespread inflammation, damaging organs such as the liver, spleen, and bone marrow. In HLH, immune cells called histiocytes and T-cells attack healthy blood cells, causing symptoms like high fever, enlarged organs, and blood abnormalities. It can occur due to infections, cancers, or genetic mutations. Prompt diagnosis and treatment are critical to control the immune response and prevent life-threatening complications.