Genetics of von Willebrand Disease

Von Willebrand Disease (vWD) is an inherited bleeding disorder caused by genetic mutations that affect the von Willebrand factor (vWF), a protein critical for blood clotting. This condition is typically passed down from parents to children through genes. There are three main types of vWD, each varying in severity and genetics. In type 1, there’s a lower level of vWF. Type 2 involves dysfunctional vWF, while type 3 is characterized by little to no vWF. Understanding these genetic factors is essential for diagnosis and management, as they influence symptoms and treatment options for those affected.