GCN5 (general control nonderepressible 5)

GCN5 (general control nonderepressible 5) is an enzyme that plays a crucial role in gene regulation by modifying proteins around DNA. It functions as a histone acetyltransferase, meaning it adds acetyl groups to histones—proteins that help package DNA in the nucleus. This modification loosens the DNA-histone interaction, making genes more accessible for activation. GCN5 is involved in processes like cell growth, differentiation, and response to signals, and is essential for proper gene expression. Its activity influences cellular functions and can impact health and disease states when disrupted.