Familial Hemophagocytic Lymphohistiocytosis

Familial Hemophagocytic Lymphohistiocytosis (FHL) is a rare, inherited condition where the immune system becomes overactive and uncontrolled. Normally, immune cells fight infections, but in FHL, these cells, called histiocytes and lymphocytes, excessively multiply and attack the body's own tissues and organs. This leads to severe inflammation, fever, enlarged organs, and potential organ failure. FHL is caused by genetic mutations affecting immune regulation, requiring early diagnosis and treatment, often involving immunosuppressive medications and bone marrow transplants, to control the disease and improve outcomes.