Familial Alzheimer's Disease Mutation

Familial Alzheimer's Disease mutations are specific genetic changes passed down through families that cause an early-onset form of Alzheimer's, typically before age 65. These mutations occur in genes involved in the production and regulation of amyloid-beta, a protein that builds up in the brain and contributes to Alzheimer’s symptoms. When these genes are mutated, they increase the likelihood of developing the disease at a younger age, often with a clear pattern of inheritance within families. Understanding these mutations helps researchers explore the biological mechanisms and develop targeted treatments for this hereditary form of Alzheimer’s.