Drug-induced cholestasis

Drug-induced cholestasis occurs when certain medications interfere with the liver’s ability to excrete bile, a digestive fluid. Bile flow is essential for digesting fats and eliminating waste, including toxins. When these drugs damage or block the bile ducts or liver cells, bile builds up in the liver and bloodstream, causing symptoms like jaundice (yellowing skin and eyes), itching, dark urine, and pale stools. This condition is usually reversible once the drug is stopped, but it requires prompt medical attention to prevent liver damage.