Dose-Limiting Toxicity

Dose-Limiting Toxicity (DLT) refers to the side effects or adverse reactions from a treatment, typically a medication or therapy, that are severe enough to prevent increasing the dose further. In clinical trials, DLT helps determine the maximum safe dose by identifying when side effects become intolerable or unsafe. It's a critical factor in balancing treatment effectiveness with patient safety, ensuring the medication’s benefits outweigh the risks without causing unacceptable harm.