DESI (Desorption Electrospray Ionization)

Desorption Electrospray Ionization (DESI) is a technique used in mass spectrometry to analyze samples directly from surfaces. It works by directing a spray of charged spray droplets onto the sample, which causes molecules to desorb (lift off) and become ionized. These ions are then captured and analyzed to identify their chemical makeup. DESI allows rapid, real-time analysis without needing extensive sample preparation, making it useful in fields like forensics, pharmaceuticals, and art conservation. Essentially, DESI enables scientists to "sniff out" the chemical composition of surfaces quickly and efficiently.