Daniel E. Koshland Jr.

Daniel E. Koshland Jr. was a renowned American biochemist known for his work in understanding how cells sense and respond to their environment. He made significant contributions to our knowledge of enzyme behavior and the process of cellular regulation, including the discovery of the allosteric effect—how molecules influence enzyme activity by binding at sites other than the active site. Koshland’s research helped clarify the dynamic nature of proteins and how cells adapt to changes, advancing molecular biology and biochemistry. His insights continue to influence scientific understanding of cellular function and regulation.