Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4)

Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4) is a protein found on the surface of certain immune cells, primarily T cells. It acts as a checkpoint regulator, helping to control the immune response. When T cells recognize and attack foreign substances, CTLA-4 can inhibit this action, preventing excessive immune reactions that could damage healthy tissues. In cancer therapy, blocking CTLA-4 can enhance the immune system's ability to target and destroy cancer cells, as it allows T cells to stay active longer. Understanding CTLA-4 is crucial for developing treatments that harness the immune system effectively.