Comparative Genomic Hybridization

Comparative Genomic Hybridization (CGH) is a laboratory technique used to detect changes in the number of copies of specific DNA segments in a genome. It compares DNA from a test sample (e.g., cancer tissue) to normal DNA, labeling each with different colors. When these are hybridized to a special slide, the colors indicate whether parts of the genome are present in normal amounts, duplicated (extra copies), or missing (deletions). This helps identify genetic abnormalities that may be linked to diseases or conditions, providing valuable insights without needing to examine individual genes.