colonic aganglionosis

Colonic aganglionosis is a condition where certain nerve cells, called ganglion cells, are missing in the large intestine (colon). These nerve cells help control bowel movements. Without them, the affected part of the colon cannot relax and move stool properly, leading to severe constipation or intestinal blockage from birth. This condition is a form of Hirschsprung's disease and often requires surgical removal of the affected segment to restore normal bowel function. Proper diagnosis and treatment are essential to prevent complications and improve quality of life.