Cholinergic Hypothesis

The cholinergic hypothesis suggests that a deficiency in the neurotransmitter acetylcholine contributes to the cognitive decline seen in Alzheimer's disease. Acetylcholine is crucial for memory, learning, and overall brain function. In Alzheimer's, the cells that produce acetylcholine are damaged or destroyed, leading to memory loss and confusion. This theory highlights the importance of cholinergic signaling in maintaining cognitive health and has influenced treatments aimed at boosting acetylcholine levels to help manage symptoms in affected individuals.