Calcitonin gene-related peptide (CGRP)

Calcitonin gene-related peptide (CGRP) is a molecule produced naturally in the body, mainly in the nervous system. It functions as a neurotransmitter and vasodilator, meaning it helps transmit signals between nerve cells and relaxes blood vessels. CGRP is especially significant in the context of migraines, as elevated levels are linked to migraine pain and sensitivity. Because of its role, treatments have been developed to block CGRP or its receptors, providing relief for many migraine sufferers. Overall, CGRP plays a key part in how the nervous system and blood vessels communicate and regulate functions like pain sensation.