Beta-cell Apoptosis

Beta-cell apoptosis is the process where insulin-producing cells in the pancreas intentionally undergo programmed cell death. This natural process can be triggered by factors like high blood sugar, inflammation, or stress, leading to a decrease in the number of these cells. When beta-cell apoptosis occurs excessively, it impairs insulin production, making it harder for the body to regulate blood sugar levels effectively. This dysfunction is a key feature in the development of diabetes, especially type 2 diabetes, and understanding it helps in researching treatments to preserve or restore beta-cell function.