BDNF polymorphism (Val66Met)

The BDNF Val66Met polymorphism is a genetic variation in the brain-derived neurotrophic factor (BDNF) gene, which influences brain health and function. BDNF is essential for neuron growth, survival, and plasticity—how the brain adapts and learns. The polymorphism involves a change from valine (Val) to methionine (Met) at position 66. People with the Met variant often have reduced BDNF activity, which can affect memory, learning, and susceptibility to mental health conditions. Understanding this variation helps researchers explore personalized approaches to treating neurological and psychiatric disorders.