Autosomal Recessive CGD

Autosomal Recessive Chronic Granulomatous Disease (CGD) is a genetic condition where certain immune cells can't effectively kill specific bacteria and fungi. This happens because of a mutation in genes inherited from both parents, leading to a defective enzyme in immune cells called phagocytes. Without this enzyme, these cells struggle to produce reactive oxygen species needed to destroy harmful pathogens. As a result, individuals with CGD are more prone to recurrent infections and inflammation, especially in the lungs, skin, and lymph nodes. The condition is inherited in an autosomal recessive pattern, meaning a person must inherit the faulty gene from both parents to be affected.