Antimitochondrial Antibodies

Antimitochondrial antibodies (AMAs) are proteins produced by the immune system that mistakenly target the mitochondria—tiny structures inside cells responsible for energy production. Their presence is most commonly associated with primary biliary cholangitis (PBC), a chronic liver disease where these antibodies attack the small bile ducts, leading to liver damage. Detecting AMAs through blood tests helps diagnose certain autoimmune conditions, especially PBC. Their presence indicates the immune system's abnormal response, not an infection, and guides appropriate management and treatment strategies.