anti-dsDNA antibodies

Anti-dsDNA antibodies are specialized proteins produced by the immune system that mistakenly target and attack the body's own DNA, specifically double-stranded DNA. These antibodies are most commonly associated with systemic lupus erythematosus (SLE), an autoimmune disease where the immune system causes inflammation and tissue damage. The presence of anti-dsDNA antibodies helps doctors diagnose and monitor SLE activity, as their levels often increase during flare-ups and decrease when the disease is under control. Their detection is useful for understanding disease severity and guiding treatment decisions.