ALK rearrangement

ALK rearrangement refers to a genetic change where the ALK gene in some cells, especially in certain lung cancers, gets abnormally fused with another gene. This fusion produces an abnormal protein that promotes uncontrolled cell growth. Recognizing ALK rearrangements helps doctors select targeted therapies that specifically inhibit this abnormal protein, improving treatment effectiveness. Detecting this rearrangement involves tests like genetic analysis of tumor samples. Overall, identifying ALK rearrangement is important for personalized cancer treatment, offering patients options tailored to the specific genetic makeup of their tumor.