Zernike phase plate

A Zernike phase plate is a specialized device used in electron microscopy to improve the contrast of biological samples. It works by subtly shifting the phase of the electron waves passing through the specimen, making transparent or faint structures more visible without increasing radiation damage. Named after the mathematician Frits Zernike, the plate is a small, precisely shaped disk that modifies electron wave interference, allowing scientists to see detailed internal features of tiny specimens like cells more clearly. This technique enhances the quality of microscopic images, aiding in detailed structural analysis.