whole-cell configuration

The whole-cell configuration is a technique used in neurobiology and electrophysiology to study the electrical activity of an entire cell, such as a neuron. In this method, a tiny glass pipette with a conductive solution is attached to the cell membrane, then used to gently break through the membrane, creating a direct electrical connection between the pipette's interior and the cell's interior. This allows scientists to measure and control the cell's electrical signals—like voltage or current—enabling detailed study of its functioning, especially how it responds to various stimuli or signals.