Variably protease-sensitive prionopathy (VPSPr)

Variably protease-sensitive prionopathy (VPSPr) is a rare neurodegenerative disease caused by abnormal proteins called prions that misfold and accumulate in the brain. These misfolded proteins disrupt normal brain function, leading to symptoms like confusion, memory loss, and movement difficulties. VPSPr can vary in presentation and progression, which makes it sometimes challenging to diagnose. Unlike other prion diseases, it may respond differently to certain tests and treatments. The exact cause is unclear, but it's associated with a specific type of genetic change in some individuals. Overall, VPSPr is part of a broader category of prion-related disorders.