Valproate Birth Defects

Valproate is a medication used to treat conditions like epilepsy and bipolar disorder. However, taking valproate during pregnancy increases the risk of birth defects in the baby. These can include issues with the brain and spinal cord (such as neural tube defects), facial features, and limbs. The risk is higher if taken during the first trimester. Because of these risks, healthcare providers carefully weigh the benefits and potential harms, and often recommend alternative medications or additional pregnancy planning to minimize the chances of birth defects.