V600E mutation

The BRAF V600E mutation is a change in a gene called BRAF that regulates cell growth. In this mutation, a specific part of the gene (the 600th amino acid) is altered from valine (V) to glutamic acid (E). This change causes the BRAF protein to become overly active, leading to uncontrolled cell division and tumor growth. The V600E mutation is common in certain cancers, such as melanoma and thyroid cancer, and understanding it helps doctors choose targeted treatments that specifically block this abnormal activity.