Tyramine interaction

Tyramine is a naturally occurring compound found in certain foods like aged cheeses, smoked meats, and some fermented products. Normally, the body breaks down tyramine using an enzyme called monoamine oxidase (MAO). However, if you're taking medications such as MAO inhibitors (commonly prescribed for depression), this enzyme's action is reduced. Without proper breakdown, tyramine levels can rise sharply, which may cause a sudden release of adrenaline. This can lead to dangerous increases in blood pressure, headaches, or even hypertensive crises. Therefore, people on MAO inhibitors are advised to limit high-tyramine foods to prevent these risks.