tTG (tissue transglutaminase)

Tissue transglutaminase (tTG) is an enzyme found mainly in your body’s tissues, such as muscles and the gut lining. It plays a key role in stabilizing proteins and helping cells repair damage. In certain autoimmune conditions like celiac disease, the immune system mistakenly targets tTG, especially when gluten is present in the diet. This leads to inflammation and damage in the small intestine. Testing for tTG antibodies helps doctors diagnose celiac disease by detecting this immune response. Overall, tTG is important for normal tissue function and plays a central role in the body's response to gluten.