Tricyclic Antidepressants

Tricyclic antidepressants (TCAs) are medications used to treat depression and certain other mental health conditions. They work by increasing the levels of chemicals in the brain called neurotransmitters—primarily serotonin and norepinephrine—that help regulate mood. TCAs influence nerve signals, improving mood, energy, and sleep. While effective, they can have side effects like drowsiness, dry mouth, and dizziness, and require careful medical supervision. Due to newer medications with fewer side effects, TCAs are now usually considered when other treatments haven't worked. They should only be taken under a healthcare provider's guidance.