translocation (EWSR1 gene)

Translocation involving the EWSR1 gene occurs when part of this gene, located on chromosome 22, swaps places with a segment of another chromosome. This abnormal exchange can create a new, fused gene that may lead to uncontrolled cell growth, contributing to certain cancers like Ewing sarcoma or some types of soft tissue tumors. Essentially, it's a genetic rearrangement that disrupts normal cell regulation, promoting tumor development. Detecting EWSR1 translocation helps diagnose specific cancers and can guide treatment options.