tPA administration guidelines

Tissue plasminogen activator (tPA) is a medication used to dissolve blood clots during certain types of stroke. It is most effective when given within a narrow time window—typically within 3 to 4.5 hours from symptom start. Before administration, healthcare providers evaluate the patient to ensure no contraindications, such as bleeding risks or recent surgeries. Imaging tests like a CT scan confirm a blocked artery without bleeding in the brain. Properly selected patients receive tPA to restore blood flow quickly, reducing brain damage and improving recovery chances. Timing and careful assessment are crucial for safe and effective use.