Tissue-type plasminogen activator (tPA)

Tissue-type plasminogen activator (tPA) is a natural enzyme in the body that helps dissolve blood clots. It works by converting plasminogen, a protein in blood, into plasmin, which breaks down fibrin—the main component of clots. Medical-grade tPA is used as a treatment for strokes caused by blood clots, helping to restore blood flow to the brain. It is most effective when given shortly after symptoms begin. While it can be life-saving, tPA must be administered carefully due to potential risks like bleeding.