The Serotonin Theory of Depression

The Serotonin Theory of Depression suggests that a deficiency or imbalance of serotonin—a neurotransmitter that influences mood, sleep, and appetite—may contribute to depression. It proposes that low levels or impaired functioning of serotonin in the brain can lead to symptoms like sadness, fatigue, and loss of interest. This theory underpins many antidepressant medications, such as SSRIs, which aim to increase serotonin levels and alleviate depressive symptoms. While it offers a helpful framework, depression is complex and involves multiple factors beyond just serotonin imbalance.