The retinoblastoma tumor-suppressor pathway

The retinoblastoma tumor-suppressor pathway involves a protein called retinoblastoma (Rb) that helps control cell growth and division. Rb acts as a gatekeeper, preventing cells from multiplying uncontrollably. When a cell is ready to divide, signals inactivate Rb, allowing the cell cycle to progress. If Rb is damaged or missing, cells can grow rapidly and form tumors, as seen in retinoblastoma and other cancers. Proper regulation of Rb is essential for preventing abnormal cell growth and maintaining healthy tissue function.