The "Phi" value

The "phi" value is a metric used in drug development to measure how well a specific genetic mutation affects the response to a particular treatment. It compares the drug’s effectiveness in patients with that mutation to those without, indicating whether the mutation makes the drug more or less effective. A positive phi suggests the mutation enhances the drug’s response, while a negative phi indicates reduced effectiveness. This helps researchers understand whether a targeted therapy is likely to benefit patients with certain genetic profiles.