The International Subarachnoid Aneurysm Trial (ISAT)

The International Subarachnoid Aneurysm Trial (ISAT) was a major research study comparing two treatments for brain aneurysms that cause bleeding: surgical clipping and endovascular coiling. The trial involved thousands of patients worldwide and found that, for certain aneurysms, coiling was linked to better survival rates and fewer complications than open surgery. The findings have influenced treatment choices, making minimally invasive coiling a preferred option for many patients with ruptured aneurysms, when appropriate. This study helped improve understanding of the safest and most effective treatments, guiding clinicians to better outcomes for patients.