Tetrahydroaminoacridine (THA)

Tetrahydroaminoacridine (THA), also known as tacrine, is a medication previously used to treat symptoms of Alzheimer's disease. It works by increasing levels of a brain chemical called acetylcholine, which is important for memory and thinking. In Alzheimer's, acetylcholine levels are often reduced, leading to cognitive decline. By boosting these levels, THA can help improve memory and mental function temporarily. However, its use has declined due to potential side effects, including liver toxicity. Overall, THA highlights the strategy of targeting brain chemicals to manage neurodegenerative conditions.