TCF/LEF

TCF (T-cell factor) and LEF (Lymphoid enhancer-binding factor) are proteins that work together as transcription factors, meaning they help turn specific genes on or off in cells. They are key players in the Wnt signaling pathway, which influences cell growth, development, and regeneration. When activated, TCF and LEF bind to DNA regions near target genes, promoting or repressing their expression. This process is essential in normal development and tissue maintenance, but when disrupted, it can contribute to diseases like cancer. In essence, TCF and LEF are molecular switches that control gene activity vital for cell function.