Tartrate-resistant acid phosphatase 5 (ACP5)

Tartrate-resistant acid phosphatase 5 (ACP5) is an enzyme produced mainly by osteoclasts, the cells responsible for breaking down bone tissue. It plays a key role in bone remodeling by aiding in the degradation of bone matrix components. Unlike other similar enzymes, ACP5 is resistant to inhibition by tartrate, which helps distinguish it during laboratory testing. Elevated levels of ACP5 can indicate increased bone breakdown, commonly seen in conditions like osteoporosis, rheumatoid arthritis, and certain cancers affecting bones. Measuring ACP5 can assist healthcare providers in diagnosing and monitoring these bone-related diseases.